Sr. Research Systems Analyst DOM Channing

Company: Mass General Brigham Health Plan, Inc.
Location: Boston
Posted on: May 3, 2025

Job Description:

Sr. Research Systems Analyst DOM Channing page is loadedSr. Research Systems Analyst DOM ChanningApply remote type Hybrid locations Boston-MA time type Full time posted on Posted Yesterday job requisition id RQ4016383 Site: The Brigham and Women's Hospital, Inc.Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.Job SummaryThe Channing Division of Network Medicine at Brigham and Women's Hospital, Boston are looking for exceptional candidates to join the Bioinformatics Core. The core work involves a wide variety of data management challenges of complex data sets, including genomic scale next-generation sequencing data, methylation, metabolomics, and proteomics. Projects involve interrogation of the genome, transcriptome, and epigenome as well as the proteome and metabolome utilizing machine learning analysis tools and data analysis pipelines running on the computational cluster and public cloud. The workflows are integrated with the software development life cycle and implement data operations best practices. The Sr. Research Systems Analyst will develop and support RECOVER System Bio OMIC Data QC needs and complex bioinformatics infrastructure needed for the review, analysis and distribution of this complex data outputs. Transformation and analysis requirements that will integrate across a wide range of skills and techniques. The Sr. Research Systems Analyst is required to design, create, support applications and software analysis pipelines and secure dissemination of information generated.QualificationsPRINCIPAL DUTIES AND RESPONSIBILITIES:

• Mentor junior bioinformaticians in assuming workflow development and application development responsibilities.
• Educate division wide RECOVER Team members through training materials and individual support. Meet with people individually to troubleshoot Bioinformatics and Data Analysis problems as well as to review coding best practices.
• Collaborate with other staff on developing workflow and system requirements.
• Build and maintain the laboratory's datasets by identifying structural and specific solutions. Evaluate requirements, prepare architecture documents, and implement those designs.
• Develop and organize cloud systems. Respond to technical issues regarding the cloud. Offer guidance in infrastructure development in the cloud.
• Prepare detailed quality control report workflows for evaluation by principal investigators and other staff members. Perform complete data validation and error detection; ensuring data security and integrity measures are met.
• Discuss with researchers to discuss results, analysis direction prior to project.
• Work closely with genetic epidemiologists and biological laboratories to design, implement, administer and support solutions to cutting edge problems in the creation and interpretation of NGS data creation.
• Maintain an active role in research of the current trends in NGS analysis methods, programming algorithms and using new technologies to prototype future developments.
• Contribute in the preparation of scientific methods for manuscripts detailing methods and design; Presentations of results or new tools at RECOVER System Bio sessions for the department.
• Perform all other duties/responsibilities as directed.QUALIFICATIONS:PhD in Computer Science, Mathematics, or a biological science recommended. Applicants will have 5+ years of programming experience developing software solutions for computational, biological or engineering problems. Understanding of agile development methods preferred.SKILLS/ ABILITIES/ COMPETENCIES REQUIRED:
• Experience programming in R, Python or Java focusing on computational biological applications.
• Experience with workflow languages like snakemake, nextflow, WDL or CWL.
• Understanding the use of bioinformatics tools including common NGS tools [plink, BWA, samtools, GATK].
• Experience with common bioinformatics and genomic browsers [NCBI, Genbank, UCSC].
• Ability to apply statistical and machine learning techniques to solve 'big data' problems.
• Experience or certification in cloud architecture; experience with HPC systems such as SGE, Slurm; experience with container technologies such as docker or kubernetes.
• Experience managing a collaborative github repository: creating issues, merging pull requests, integrating code from multiple team members.
• Experience with "full-stack development" a plus, including code development; continuous integration; testing; packaging; deployment.
• Ability to work in a highly collaborative and intellectually challenging environment.
• Must work independently.
• Excellent oral and written communication skills.Additional Job Details (if applicable)Additional Job DescriptionRemote TypeHybridWork Location181 Longwood AvenueScheduled Weekly Hours40Employee TypeRegularWork ShiftDay (United States of America)EEO Statement:The Brigham and Women's Hospital, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)-282-7642.Mass General Brigham Competency FrameworkAt Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.Why work here?Combat disease. Hold a hand. Help people. Impact the world.Mass General Brigham is a passionate, welcoming community where minds meet caring hearts.Come be a part of the world's most powerful force in medicine, where every role is important in changing lives. Are you ready?About Us?Our history includes New England hospitals founded over 200 years ago, some of the first and most prestigious hospitals in the world.Built on the legacy of two leading academic medical centers, we're more than a system-we're leaders in the practice of medicine. Mass General Brigham is committed to serving the community.We are dedicated to enhancing patient care, teaching and research, and taking a leadership role as an integrated health care system.We recognize that increasing value and continuously improving quality are essential to maintaining excellence.
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Keywords: Mass General Brigham Health Plan, Inc., Framingham , Sr. Research Systems Analyst DOM Channing, Professions , Boston, Massachusetts