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Bioinformatics Scientist Next Generation Sequencing

Company: myGwork
Location: Framingham
Posted on: September 17, 2022

Job Description:

Position Overview: We are seeking a motivated Bioinformatics Scientist to join the Next Generation Sequencing (NGS) Core group to support genomic analyses of multiple therapeutic modalities within the Genomic Medicine Unit (GMU) CMC organization. The role is responsible for leading analysis driven projects, interfaced within a cross-functional team, to develop and implement genomic analytical solutions for programs spanning precandidate selection through commercialization. The ideal candidate will be expected to support end-to-end NGS solutions, through wet-lab method development to analytical pipeline design and execution, with a focus on dry-lab applications. Ability and desire to learn and develop wet-lab molecular skills is required. Key Responsibilities:

  • Support computational needs for the development and validation of NGS-based assays and DNA sequencers.
  • Work closely with a multi-disciplinary team of scientists and engineers to implement genomic analytical solutions for programs spanning precandidate selection through commercialization.
  • Develop, execute, and maintain NGS analysis pipelines for execution in cloud-based computational environments.
  • Develop and execute complex molecular biology protocols, specifically various NGS-based library preparation and characterization protocols, using established molecular biology techniques and novel solutions.
  • Keep records of development work and testing in a GxP environment utilizing electronic notebook solutions.
  • Write publications for scientific journals.
  • Represent the group at internal and external conferences. Basic Qualifications:
    • Ph.D. in a relevant computer science discipline or a Master's degree with a minimum of 4 years of relevant industry experience or a Bachelor's degree with a minimum of 6 years of relevant industry experience.
    • Minimum of 2 years' experience with NGS, spanning knowledge of wet-lab protocols and hands-on dry-lab experience.
    • Expertise in bioinformatics with a working understanding of genomic analysis solutions (e.g., FastQC, Bowtie2, SAMtools, NCBI BLAST+, Nextflow, Snakemake, etc.).
    • Scripting experience in coding languages (e.g., bash, awk, Python, R, etc.).
    • Expertise in setting up cloud-based solutions to host and execute NGS analysis pipelines.
    • Advanced understanding of NGS platforms, specifically those utilizing the synthesis by sequencing technique (i.e., Illumina platforms).
    • Familiarity with custom software validation regulations.
    • Ability to work independently and adapt under aggressive and/or changing timelines.
    • Proven experience working across functions Preferred Qualifications:
      • Familiarity with scripting environments and paradigms (e.g., Git).
      • Familiarity with liquid handlers and other automation tools.
      • Expertise with basic molecular biology techniques (e.g., ligation, PCR, and qPCR) as well as nucleic acid extraction and analysis techniques (e.g., Nanodrop, DNA fragment analyzers, ddPCR, etc.).
      • Knowledge of and experience with other sequencing platforms (i.e., PacBio Sequel II).
      • Prior experience in leading the internalization of custom NGS analysis pipelines is highly preferred.
      • Wet-lab method development experience to support NGS workflows. At Sanofi R&D North America, we deliver meaningful solutions for patients. We transform science into breakthrough, best-in-class and first-in-class medicines and vaccines. We believe in creating a diverse and inclusive workforce - and workplace - which brings together the collective brainpower of over 2,000 colleagues and provides you with an exciting place to grow and develop. We set the bar high, and we deliver. Join us and together we will build on our trusted legacy of breakthroughs for society. Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law. As a healthcare company and a vaccine manufacturer, Sanofi has an important responsibility to protect individual and public health. All US based roles require individuals to be fully vaccinated against COVID-19 as part of your job responsibilities. Fully vaccinated, according to the CDC, an individual is considered to be "fully vaccinated" fourteen (14) days after receiving (a) the second dose of the Moderna or Pfizer vaccine, or (b) the single dose of the J&J vaccine. Fully vaccinated, for new Sanofi employees, is to be fully vaccinated 14 DAYS PRIOR TO START DATE. #GD-SA
        #LI-SA PDN At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all. This employer is a corporate member of
        myGwork - LGBTQ+ professionals, the business community for LGBTQ+ professionals,
        students, inclusive employers & anyone who believes in workplace equality.

Keywords: myGwork, Framingham , Bioinformatics Scientist Next Generation Sequencing, Other , Framingham, Massachusetts

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