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Senior Scientist, Investigative Toxicology

Company: Sanofi
Location: Framingham
Posted on: September 13, 2022

Job Description:

Job overview Sanofi's Investigative Toxicology group is looking to hire a motivated and enthusiastic scientist interested in performing hypothesis-driven research to uncover the mechanisms that lead to unexpected toxicity of therapeutic modalities by using a combination of independent scientific literature analysis and wet lab studies. As such, the scientist needs to be proactive, a self-starter, and must have experience working with primary mammalian cell cultures or physiologically relevant advanced 3D assays to implement fit-for-purpose in vitro cellular models for safety assessment studies. By working with a cross-functional team of pathologists, DMPK scientists, medicinal chemists, and project safety representatives, the incumbent will help deconvolute toxic liabilities to enable advancement of compound for discovery and development programs. The successful candidate must have good collaborative skills to smoothly work with Sanofi colleagues across sites and with external vendors, a high level of scientific rigor in their work, and exemplary communication skills to excel in Sanofi's matrix environment. This position will be extremely rewarding as it will allow the candidate to push the boundaries of science while simultaneously help bring innovative and safe medicines to the patients. Responsibilities

  • Develop and optimize fit-for-purpose in vitro cellular models, including providing technical expertise, design and execute qualification plans, and establish relevant endpoint assays to dissect the molecular mechanisms of toxicity.
  • Independently review literature to generate hypotheses for experimental testing. - Design and execute relevant experiments to test hypotheses, including data analysis and its interpretation.
  • Assist in the development of de-risking strategies for various organ systems related to liver, kidney, vascular, and/or immune system.
  • Identification and development of translative biomarkers.
  • Supervise and mentor the lab's technical staff, as needed.
  • Collaborate with external vendors on technology and assay evaluation, where appropriate.
  • Work with project teams to address and investigate safety mechanisms and help projects meet their development timelines.
  • Author investigative reports to support inclusion of results in regulatory submissions as needed.
  • Represent Sanofi on external consortia and serve as the SME. Requirements & Qualifications
    • PhD in toxicology, pharmacology, immunology, cellular biology, or equivalent biological field with at least 3 years of relevant research experience in an academic or biopharmaceutical setting or a Master's degree with at least 5 years of experience.
    • Proven experience and expertise in mammalian cell culture (primary, iPSC), imaging (high content, confocal), molecular biology (RNA, DNA, protein) endpoints, and biochemical endpoints (ELISAs, Luminex/MSD) is a must.
    • Proven record of scientific contribution in peer-reviewed journals and invited talks.
    • Excellent verbal and written communication skills. - - -
    • Experience in liver biology, in vitro culture of hepatocytes and Kupffer cells, is a plus.
    • Working knowledge of microphysiological system/organ-on-a-chip, 3D models, or complex in vitro systems will also be a significant advantage. Terms of employment
      • Occasional domestic travel to scientific conferences as permitted by Sanofi travel policies. Availability to start in Q3 2022. Benefits of working in this role
        • Be part of an active, innovative scientific group
        • Gain broad expertise in safety assessment studies at a large pharma
        • Have diverse opportunities to collaborate globally
        • Be highly recognized for success
        • Receive excellent benefits and compensation Location information
          • The position is based in Framingham, MA until end of summer and then located in Cambridge, MA. At Sanofi R&D North America, we deliver meaningful solutions for patients. We transform science into breakthrough, best-in-class and first-in-class medicines and vaccines. We believe in creating a diverse and inclusive workforce - and workplace - which brings together the collective brainpower of over 2,000 colleagues and provides you with an exciting place to grow and develop. We set the bar high, and we deliver. Join us and together we will build on our trusted legacy of breakthroughs for society. - Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law. As a healthcare company and a vaccine manufacturer, Sanofi has an important responsibility to protect individual and public health. All US based roles require individuals to be fully vaccinated against COVID-19 as part of your job responsibilities. According to the CDC, an individual is considered to be "fully vaccinated" fourteen (14) days after receiving (a) the second dose of the Moderna or Pfizer vaccine, or (b) the single dose of the J&J vaccine. Fully vaccinated, for new Sanofi employees, is to be fully vaccinated 14 DAYS PRIOR TO START DATE. - - #GD-SA
            #LI-SA PDN At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

Keywords: Sanofi, Framingham , Senior Scientist, Investigative Toxicology, Other , Framingham, Massachusetts

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