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Senior System and Controls Engineer

Company: CRISPR Therapeutics
Location: Framingham
Posted on: August 6, 2022

Job Description:

Company Overview

CRISPR Therapeutics is a leading gene editing company focused on developing transformative gene-based medicines for serious diseases using its proprietary CRISPR/Cas9 platform. CRISPR/Cas9 is a revolutionary gene editing technology that allows for precise, directed changes to genomic DNA. CRISPR Therapeutics has established a portfolio of therapeutic programs across a broad range of disease areas including hemoglobinopathies, oncology, regenerative medicine, and rare diseases. To accelerate and expand its efforts, CRISPR Therapeutics has established strategic collaborations with leading companies including Bayer, Vertex Pharmaceuticals and ViaCyte, Inc. CRISPR Therapeutics AG is headquartered in Zug, Switzerland, with its wholly-owned U.S. subsidiary, CRISPR Therapeutics, Inc., and R&D operations based in Boston, Massachusetts, and business offices in San Francisco, California and London, United Kingdom.

Job Summary

This position will report directly to Head of Process Engineering and be located at the state-of-the-art virus and cell therapy manufacturing facility at 33 New York Ave, Framingham, MA.


  • Integration of equipment with SCADA including panel, wiring, and IO design and verification
  • Specification of automated skids, controllers, and instrumentation
  • Generation of instrument calibration requirements and justification
  • Support commissioning and qualification as I&C SME
  • Ongoing support of building and equipment automation (troubleshooting) and implementing continuous improvement opportunities
  • Liaison between equipment system owners within Manufacturing, Facilities, and Engineering and automation programming and integration engineers.
  • Provide technical guidance and analysis for the resolution of equipment controls related deviations and investigations
  • Lead implementation of process improvement projects through change control
  • Develop department procedures and specifications
    • Experience in system, network, hardware and control panel design for manufacturing equipment including HMIs, SCADA systems, and PLCs
    • Excellent attention to detail and capable of managing multiple priorities with aggressive timelines
    • Strong interpersonal communication skills and ability to work effectively with internal cross functional teams and external partners and vendors
    • Proficient at applying good engineering practices, industry guidances, and regulatory requirements
    • Creative problem solver and decision maker
    • Bachelor's degree in Engineering or related field or Licensed Electrician with 5+ years experience in a cGMP manufacturing environment
    • Experience with OPC, analog, bus, networks, etc
    • General programming and troubleshooting background with PLCs, DCS, HMI, SCADA
    • Basic knowledge of UL508, UL508A, NFPA 70, NFPA79, and NFPA79A.
    • Experience with Rockwell PlantPAx, OSI Pi, and Blue Mountain CMMS a plus
      CRISPR Therapeutics, Inc. is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.

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Keywords: CRISPR Therapeutics, Framingham , Senior System and Controls Engineer, Other , Framingham, Massachusetts

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