Scientist CMC Developability & Preformulation Sciences

Company: Sanofi
Location: Framingham
Posted on: June 25, 2022

Job Description:

Job Responsibilities:We are seeking a highly motivated and talented Scientist to join our Developability & Preformulation Sciences (DPFS) group.DPFS is part of the global Biologics Drug Product Development and Manufacturing (BioDPD&M) organization, a critical R&D function enabling the manufacturing of stable and deliverable dosage forms along the complete development timeline from molecule selection to commercial tech transfer.Be part of a team with global responsibility for enabling candidate selection within Sanofi's promising pipeline of biotherapeutics and for determining the formulation design space for a variety of biotherapeutic modalities.Help chart the roadmap to continuously improving capabilities in the prediction, characterization, and control of the molecular liabilities that limit the development of stable and manufacturable drugs.Serve as a team and technical leader in BioDPD&M, where you will act as a critical facilitator of the Research-to-Development transition and play an important role in laying the foundation for successful commercial formulations.Be responsible for planning and executing developability assessments and preformulation workflows, collaborating with colleagues in discovery, protein engineering, analytics, drug substance process development, and project management.Design and lead laboratory research focused in the areas of therapeutic candidate credentialing technologies, characterization of protein solution properties, and the molecular basis of high concentration behaviors.Basic Qualifications:PhD in Biochemistry or a related discipline or a Master's degree with a minimum of 4 years of relevant laboratory experience or a Bachelor's degree with a minimum of 6 years of experienceKnowledge of proteins (antibody and AAV caspid is preferred)Broad working knowledge of biochemical and biophysical characterization methods such as chromatography, CE-SDS, gel electrophoresis and western blotting, UV/CD/fluorescence spectroscopies, calorimetry, light scattering, and sedimentationStrong work ethic, team- and project-focused, and motivated to produce high quality data on an aggressive timeline.Solid understanding of protein structure, chemistry, and degradation mechanismsGood leadership qualities and an established track record of cross-functional project managementPreferred Qualifications:Good communication and presentation skillsKnowledge of the fundamental biopharmaceutical principles of developing injectable biologic drug products.iLab experience is highly desirable.Experience with AAVs to support drug product development of a gene therapy program.Pursue progress, discover extraordinaryBetter is out there. Better medications, better outcomes, better science. But progress doesn't happen without people - people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let's be those people.At Sanofi, we provide equal opportunities to all regardless of race, colour, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, or gender identity. Watch our ALL IN video and check out our Diversity Equity and Inclusion actions at sanofi.comAt Sanofi R&D North America, we deliver meaningful solutions for patients. We transform science into breakthrough, best-in-class and first-in-class medicines and vaccines. We believe in creating a diverse and inclusive workforce - and workplace - which brings together the collective brainpower of over 2,000 colleagues and provides you with an exciting place to grow and develop. We set the bar high, and we deliver. Join us and together we will build on our trusted legacy of breakthroughs for society.Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.As a healthcare company and a vaccine manufacturer, Sanofi has an important responsibility to protect individual and public health. All US based roles require individuals to be fully vaccinated against COVID-19 as part of your job responsibilities.Fully vaccinated, according to the CDC, an individual is considered to be "fully vaccinated" fourteen (14) days after receiving (a) the second dose of the Moderna or Pfizer vaccine, or (b) the single dose of the J&J vaccine. Fully vaccinated, for new Sanofi employees, is to be fully vaccinated 14 DAYS PRIOR TO START DATE. GD-SALI-SAPDNAt Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.PDN-96008640-87f8-4f67-b710-1617ee577f60

Keywords: Sanofi, Framingham , Scientist CMC Developability & Preformulation Sciences, Other , Framingham, Massachusetts