Senior Scientist Cell Line Development

Company: Sanofi
Location: Framingham
Posted on: June 25, 2022

Job Description:

Job overview/Department descriptionThe Genomic Medicine Unit (GMU) CMC group at Sanofi is dedicated to the establishment of best-in-class manufacturing platforms to support development of life-changing advanced cell and gene therapy products. We seek a highly motivated candidate to join Cell Line Development (CLD), as part of a team focused on cell line generation activities for Sanofi's Genomic Medicine Unit (GMU) pipeline.The person in this role will be leading CLD lab activities and work in a high-performing, fast-paced collaborative environment, ensure project goals and timelines are met by delivering producer cell lines expressing viral vectors for gene therapy, and support multiple efforts to optimize our future producer cell line viral vector platform. Work will directly support development projects within Sanofi's pipeline.The position also provides the opportunity to work on cross-functional teams, contribute to operational excellence and other transversal initiatives, and have a direct impact on shaping our future cell line expression platforms. The GMU CLD group is currently operational in Framingham, MA and will relocate to the newly designed lab space in Waltham, MA in the second half of 2022.Key ResponsibilitiesTechnical oversight of end-to-end producer cell line development work packages to meet deliverables for preclinical and clinical development projects, including reports and presentations to stakeholdersManage scientists performing AAV producer cell line development and technology development activitiesPrepare and review documentation for regulatory submissionsRepresent the CLD function on project teams and within GMU CMC, making decisions for cell line activities and effectively communicating results, progress and plansDrive innovation strategies for generating cell lines and improving AAV viral vector production, to ensure "right first time" delivery of commercial-ready cell linesConceptualization, design, execution and analysis of studies to optimize cell line generation process towards development of an automation-enabled high-throughput NextGen producer cell line platformCompliance with all applicable regulations, ensure that work performed is conducted in a safe and compliant manner, ensure maintenance of proper records in accordance with SOPs and policiesBasic QualificationsPhD in Biology, Cell Biology, Bioengineering, or related discipline with a minimum of 4 years of relevant experience or Master's degree with a minimum of 8 years of relevant experience or Bachelor's degree with a minimum of 10 years of relevant experienceHands-on experience in mammalian cell line development in a pharmaceutical or biotechnology settingStrong technical background and experience in viral vector production, preferably recombinant AAV vectorsAt least 2 years of people management experienceStrong molecular biology background, preferably with insights into AAV biologySelf-motivated with excellent communication, organization, time-management skillsDemonstrated ability to work in a highly collaborative environment and adhere to timelinesPreferred QualificationsSuspension mammalian cell culture experience in a pharmaceutical or biotechnology settingExperience with automation and/or high throughput technologies as applied to mammalian cell line generation and process optimization is highly preferredExperience in mammalian gene expression systems, gene editing and/or 'omics technologiesFlexibility and a willingness to expand skill set and responsibilities in a past-faced team environmentSanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.At Sanofi R&D North America, we deliver meaningful solutions for patients. We transform science into breakthrough, best-in-class and first-in-class medicines and vaccines. We believe in creating a diverse and inclusive workforce - and workplace - which brings together the collective brainpower of over 2,000 colleagues and provides you with an exciting place to grow and develop. We set the bar high, and we deliver. Join us and together we will build on our trusted legacy of breakthroughs for society.As a healthcare company and a vaccine manufacturer, Sanofi has an important responsibility to protect individual and public health. This position will require individuals to be fully vaccinated against COVID-19 as part of your job responsibilities.GD-SALI-SAPDNAt Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.PDN-95ba1eae-7fcf-4c83-be1b-9b031337ac77

Keywords: Sanofi, Framingham , Senior Scientist Cell Line Development, Other , Framingham, Massachusetts