Scientist Next Generation Sequencing
Company: Principia Biopharma Inc.
Posted on: June 8, 2021
We are seeking a motivated Scientist to join the newly formed
Next Generation Sequencing (NGS) Core group to support genomic
analyses of multiple therapeutic modalities within the Genomic
Medicine Unit (GMU) CMC organization. The role is responsible for
leading projects, interfaced within a cross-functional team, to
develop and implement genomic analytical solutions for programs
spanning precandidate selection through commercialization. The
ideal candidate will be expected to develop NGS sample preparation
methods using established molecular biology techniques and by
exploring novel solutions.
Develop NGS sample preparation methods to characterize and
release various biopharmaceutical candidates including monoclonal
antibodies, viral vectors for gene therapy, and cell lines.
Lead project teams comprised from analytical and data sciences
groups to develop and implement genomic analytical solutions for
programs spanning precandidate selection through
Identify and implement new technologies to accelerate NGS
Develop and execute complex molecular biology protocols,
specifically various NGS-based library preparation and
characterization protocols, using established molecular biology
techniques and novel solutions.
Communicate with internal stakeholders to provide develop
customs analysis solutions and provide troubleshooting support.
Provide technical support to existing methods and analysis
Keep records of development work and testing in a GxP
environment utilizing electronic notebook solutions.
Write technical reports and method/instrument SOPs.
Method and instrument qualification and validation.
- Represent the group at external conferences.
Ph.D. in a relevant biology discipline or a Master's degree with
a minimum of 4 years of relevant industry experience or Bachelor's
degree with a minimum of 6 years of relevant industry
Minimum of 2 years' experience with NGS, spanning DNA extraction
through sample analysis.
Expertise with basic molecular biology techniques (i.e.,
ligation, PCR, and qPCR) as well as nucleic acid extraction and
analysis techniques (i.e., Nanodrop, DNA fragment analyzers, ddPCR,
Advanced understanding of NGS platforms, specifically those
utilizing the synthesis by sequencing technique (i.e., Illumina
High-level understanding of NGS analysis pipeline setup and
Practical method qualification and validation experience using
quality by design.
Familiarity with instrument and software validation
- Ability to work independently and adapt under aggressive and/or
Familiarity with liquid handlers and other automation tools.
Knowledge of and/or experience with other sequencing platforms
(i.e., PacBio Sequel II).
Scripting experience in coding languages (i.e., bash, awk,
python, R, etc.) is preferred.
- Experience mentoring junior staff is highly preferred.
Sanofi Inc. and its U.S. affiliates are Equal Opportunity and
Affirmative Action employers committed to a culturally diverse
workforce. All qualified applicants will receive consideration for
employment without regard to race; color; creed; religion; national
origin; age; ancestry; nationality; marital, domestic partnership
or civil union status; sex, gender, gender identity or expression;
affectional or sexual orientation; disability; veteran or military
status or liability for military status; domestic violence victim
status; atypical cellular or blood trait; genetic information
(including the refusal to submit to genetic testing) or any other
characteristic protected by law.
At Sanofi diversity and inclusion is foundational to how we
operate and embedded in our Core Values. We recognize to truly tap
into the richness diversity brings we must lead with inclusion and
have a workplace where those differences can thrive and be
leveraged to empower the lives of our colleagues, patients and
customers. We respect and celebrate the diversity of our people,
their backgrounds and experiences and provide equal opportunity for
Keywords: Principia Biopharma Inc., Framingham , Scientist Next Generation Sequencing, Other , Framingham, Massachusetts
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