Senior Scientist Next Generation Sequencing
Company: Principia Biopharma Inc.
Posted on: June 8, 2021
We are seeking a motivated Senior Scientist to join the newly
formed Next Generation Sequencing (NGS) Core group to support
genomic analyses of multiple therapeutic modalities within the
Genomic Medicine Unit (GMU) CMC organization. The role is
responsible for strategically leading projects, interfaced within a
cross-functional team, to develop and implement genomic analytical
solutions for programs spanning precandidate selection through
commercialization. The ideal candidate will be expected to support
end-to-end NGS solutions, through wet-lab method development to
analytical pipeline design and execution.
Develop NGS sample preparation methods to characterize and
release various biopharmaceutical candidates including monoclonal
antibodies, viral vectors for gene therapy, and cell lines.
Lead project teams comprised from analytical and data sciences
groups to develop and implement genomic analytical solutions for
programs spanning precandidate selection through
Develop and execute complex molecular biology protocols,
specifically various NGS-based library preparation and
characterization protocols, using established molecular biology
techniques and novel solutions.
Develop and execute NGS analysis pipelines for execution in a
cloud-based computational environment.
Lead and implement technology development to accelerate NGS
Potentially manage and lead a team of scientists including the
coordination of workload across the group.
Communicate with internal stakeholders to provide develop
customs analysis solutions and provide troubleshooting support.
Provide technical support to existing solutions.
Keep records of development work and testing in a GxP
environment utilizing electronic notebook solutions.
Write publications for scientific journals.
- Represent the group at external conferences.
Ph.D. in a relevant discipline with a minimum of 4 years of
relevant industry experience or a Master's degree with a minimum of
8 years of relevant industry experience or Bachelor's degree with a
minimum of 10 years of relevant industry experience.
Minimum of 2 years' experience with NGS, spanning DNA extraction
through sample analysis.
Expertise with basic molecular biology techniques (i.e.,
ligation, PCR, and qPCR) as well as nucleic acid extraction and
analysis techniques (i.e., Nanodrop, DNA fragment analyzers, ddPCR,
Expertise in bioinformation with a working understanding of
genomic analysis solutions (i.e., FastQC, Bowtie2, SAMtools, NCBI
Scripting experience in coding languages (i.e., bash, awk,
python, R, etc.).
Expertise in setting up clod-based solutions to host and execute
NGS analysis pipelines.
Advanced understanding of NGS platforms, specifically those
utilizing the synthesis by sequencing technique (i.e., Illumina
Familiarity with custom software validation regulations.
Proven experience and ability to lead projects within a cross
Track record of publications in high quality journals.
- Ability to work independently and adapt under aggressive and/or
Familiarity with liquid handlers and other automation tools.
Previous management experience is highly preferred.
Knowledge of and experience with other sequencing platforms
(i.e., PacBio Sequel II) is highly preferred.
- Prior experience in leading the internalization of custom NGS
analysis pipelines is highly preferred.
Sanofi Inc. and its U.S. affiliates are Equal Opportunity and
Affirmative Action employers committed to a culturally diverse
workforce. All qualified applicants will receive consideration for
employment without regard to race; color; creed; religion; national
origin; age; ancestry; nationality; marital, domestic partnership
or civil union status; sex, gender, gender identity or expression;
affectional or sexual orientation; disability; veteran or military
status or liability for military status; domestic violence victim
status; atypical cellular or blood trait; genetic information
(including the refusal to submit to genetic testing) or any other
characteristic protected by law.
At Sanofi diversity and inclusion is foundational to how we
operate and embedded in our Core Values. We recognize to truly tap
into the richness diversity brings we must lead with inclusion and
have a workplace where those differences can thrive and be
leveraged to empower the lives of our colleagues, patients and
customers. We respect and celebrate the diversity of our people,
their backgrounds and experiences and provide equal opportunity for
Keywords: Principia Biopharma Inc., Framingham , Senior Scientist Next Generation Sequencing, Other , Framingham, Massachusetts
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