Senior Associate Scientist - Recombinant Protein Production
Company: Principia Biopharma Inc.
Posted on: June 6, 2021
We are seeking a highly motivated individual to join our dynamic
and innovative team of scientists in US Large Molecule Research
Protein Production. We are dedicated to the rapid expression and
purification of recombinant proteins and antibodies to advance
exciting discovery research projects in Sanofi's portfolio spanning
Oncology, Immunology and Inflammation, Neuroscience and Rare blood
Expression of recombinant proteins and antibodies employing a
range of host cell systems using cutting edge as well as
established technical procedures.
Purification of recombinant proteins and antibodies using
affinity-based and/or conventional chromatographic separation
techniques; use of automated purification platforms such as
Characterization of produced proteins and antibody drug
candidates using SDS-PAGE, analytical SEC, endotoxin analysis,
immunoblotting, SPR, flow cytometry, or related techniques.
- Documentation, analysis and presentation of data in
well-organized written and oral formats.
Requires a MS with a minimum of 1 year industry experience, or a
BS with a minimum of 4 years industry experience.
Past lab experience must include hands on research experience
and the ability to apply technical skills in the areas of cell
culture, mammalian cell transient transfection and the purification
of recombinant proteins.
- The candidate should have effective communication skills, the
ability to work effectively in a collaborative team environment,
and present data in well-organized written and oral formats
Experience in protein expression using suspension cultures of
mammalian cells (HEK, CHO) as well as insect cells and/or E. coli
employing transient and stable expression technologies.
Hands on experience using automated protein purification systems
such as AKTA or similar.
Demonstrated ability to innovate in the areas of cell culture
and mammalian cell expression.
Prior experience with protein analytical techniques such as
BIAcore, SDS-PAGE, immunoblotting, etc.
- Prior hands on experience with high throughput expression and
purification platforms and/or production and characterization of
multi-specific antibody formats.
Sanofi Inc. and its U.S. affiliates are Equal Opportunity and
Affirmative Action employers committed to a culturally diverse
workforce. All qualified applicants will receive consideration for
employment without regard to race; color; creed; religion; national
origin; age; ancestry; nationality; marital, domestic partnership
or civil union status; sex, gender, gender identity or expression;
affectional or sexual orientation; disability; veteran or military
status or liability for military status; domestic violence victim
status; atypical cellular or blood trait; genetic information
(including the refusal to submit to genetic testing) or any other
characteristic protected by law.
At Sanofi diversity and inclusion is foundational to how we
operate and embedded in our Core Values. We recognize to truly tap
into the richness diversity brings we must lead with inclusion and
have a workplace where those differences can thrive and be
leveraged to empower the lives of our colleagues, patients and
customers. We respect and celebrate the diversity of our people,
their backgrounds and experiences and provide equal opportunity for
Keywords: Principia Biopharma Inc., Framingham , Senior Associate Scientist - Recombinant Protein Production, Other , Framingham, Massachusetts
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