Senior Scientist, Purification Development
Company: Principia Biopharma Inc.
Posted on: June 1, 2021
Purification Process Development (PPD) is an R&D department
within the Sanofi Global CMC Development organization. PPD is
responsible for development, scale-up, transfer and
characterization of downstream processes for early and late stage
clinical and commercial manufacturing of therapeutic proteins,
hormones and antibodies. In addition, the department develops
next-generation commercial processes, develops and implements new
technologies, and supports and updates our global purification
platform. The department also has particular expertise in the area
of integrated and continuous bioprocessing and is actively working
toward the advancement of this field.
We are looking for candidates for the position of Senior
Scientist. This individual should be able to independently plan and
lead complex projects or studies, serve in cross-functional or
cross-site roles and contribute to PPD strategy and culture, while
ensuring the highest standards of safety, environmental and
regulatory compliance are maintained in the workplace.
Leading teams of purification scientists to develop purification
processes for clinical and/or commercial manufacturing.
Developing and managing plans to achieve objectives, planning
and prioritizing resource requirements and allocations within a
functional team or for a cross-functional project.
Applying technical and platform knowledge to design studies,
assist in project design and independently complete work while
representing PPD in transversal projects or cross-site
Potentially managing junior team members and providing technical
guidance and support.
Staying informed of relevant new technologies and initiating the
development of impactful and appropriate new technologies.
Applying scientific expertise and technical knowledge to
initiate, design, direct and execute experiments and/or studies in
support of CMC project goals and technology development goals.
Analyzing, interpreting and presenting results internally for
governance and technical meetings.
Serving as a subject-matter expert in areas such as purification
process development, high throughput techniques, and/or continuous
Demonstrating continuous growth in depth and breadth of
technical expertise and understanding of strategic goals of the
group and team.
Establishing good communications and collaborative relationships
with cross-functional colleagues.
- Contributing to the scientific literature and conferences,
gaining recognition as a subject-matter expert in both internal and
external purification communities.
Ph.D. or advanced degree in Chemical Engineering, Biochemical
Engineering, Biochemistry, Biology or related discipline with a
minimum of 4 years of relevant industry experience or a Master's
degree with a minimum of 8 years or a Bachelor's degree with a
minimum of 10 years of relevant industry experience.
- Knowledge and understanding of production and purification of
Experience with process modeling, process controls, and
mathematical and statistical approaches.
Has advanced knowledge of the principles, concepts and practices
of various aspects of a purification process development and basic
knowledge of principles and concepts in other relevant
Experience in process transfer and scale-up to clinical and/or
Demonstrated ability to function in a matrix and
collaborative/team oriented environment.
- Demonstrated passion for scientific innovation through patents,
publications and presentations.
Sanofi Inc. and its U.S. affiliates are Equal Opportunity and
Affirmative Action employers committed to a culturally diverse
workforce. All qualified applicants will receive consideration for
employment without regard to race; color; creed; religion; national
origin; age; ancestry; nationality; marital, domestic partnership
or civil union status; sex, gender, gender identity or expression;
affectional or sexual orientation; disability; veteran or military
status or liability for military status; domestic violence victim
status; atypical cellular or blood trait; genetic information
(including the refusal to submit to genetic testing) or any other
characteristic protected by law.
At Sanofi diversity and inclusion is foundational to how we
operate and embedded in our Core Values. We recognize to truly tap
into the richness diversity brings we must lead with inclusion and
have a workplace where those differences can thrive and be
leveraged to empower the lives of our colleagues, patients and
customers. We respect and celebrate the diversity of our people,
their backgrounds and experiences and provide equal opportunity for
Keywords: Principia Biopharma Inc., Framingham , Senior Scientist, Purification Development, Other , Framingham, Massachusetts
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