Senior Research Associate - Bioassay Analytical Development

Company: Principia Biopharma Inc.
Location: Framingham
Posted on: June 1, 2021

Job Description:

Position Overview:

We are seeking an energetic and highly motivated Senior Research Associate to join the cell-based bioassay team in the BioAnalytical Development group, which establishes phase appropriate control strategies and to develop, qualify, and validate robust analytical methods to support release and characterization testing of biologics therapeutics. In addition, the group supports GMP-compliant release and stability testing of clinical supplies. The candidate will have the opportunity to work on different modalities such as monoclonal antibodies, multi-specific antibodies, therapeutic enzymes, and gene and cell therapies.

Key Responsibilities:

* Engineer cell lines with which to evaluate the relative potency and mechanism of action for biologics including reporter gene cell lines, mutants and other control cells.

* Support routine cell culture activities.

* Support routine sample testing for drug substance/drug product in potency assays, utilizing molecular and cell readouts such as PCR, spectrophotometer, luminometer and imaging cytometer, and entering data in the LIMS system.

* Independently plan, prioritize, execute and evaluate experiments.

* Analyze, compile and present results to internal and cross functional teams comprised of members from multiple groups and stakeholders.

* Maintain a strong work ethic and good documentation practices using the electronic lab notebook system.

* Maintain GMP compliance by following GMP procedures in the laboratory, by supporting routine maintenance activities in the department, and by training on drafting appropriate SOPs.

Basic Qualifications:

* A Master's degree in molecular/cell biology, biochemistry, pharmaceutical science or a related discipline, or a Bachelor's degree with a minimum of 2 years relevant industry experience.

* Experience with mammalian cell culture and molecular/cell techniques such as PCR, cloning, western, imaging cytometry and spectrophotometry.

* Excellent communication and collaboration skills.

* Ability to multi-task and learn new skills in a fast-paced team environment.

* Must have permanent US work authorization

Preferred Qualifications:

* At least one year of experience in a GMP environment.

* Experience with cell line engineering, transfection and transduction.

* Experience/working knowledge of flow cytometry.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

Keywords: Principia Biopharma Inc., Framingham , Senior Research Associate - Bioassay Analytical Development, Other , Framingham, Massachusetts