Company: Principia Biopharma Inc.
Posted on: May 31, 2021
At Sanofi we are committed in our quest to be a world-class
biologics research organization and are steadfast in our goal to
bring next generation, transformative therapies to patients. Our
global Large Molecule Research (LRM) platform consists of five
sites, and approximately 550 personnel focused on antibodies,
nanobodies and synthorins as therapeutic modalities. Our platform
enables and partners closely with other research platforms and
Sanofi's therapeutic areas (Immunology, Oncology, Rare Disease and
Neurology) in the discovery and ultimate delivery of new candidate
molecules into our pipeline.
To continue to build on our success in these efforts we are
seeking an experienced, versatile, and self-driven individual to
join the Antibody Discovery group at our US Boston site. This
position will play a critical role in shaping lead discovery
efforts of next generation biotherapeutics in Immunology and IO
therapeutic areas, with strong focus on multi-specific modalities.
The successful candidate will have demonstrated in-depth
understanding of in vitro display (i.e., mammalian, phage or yeast)
methodologies, antibody discovery workflows, protein engineering,
sequence analysis and excel in a fast-paced environment. The
candidate will be responsible for advanced lab activities, project
leadership and is expected to impact at the organizational level in
a matrix team environment.
This is an exciting opportunity to join a group of accomplished
scientists focused on the design and realization of advanced
therapeutic modalities, including multi-specific antibodies such as
those that have recently entered the clinic (see: DOI:
10.1126/science.aan8630 and DOI: 10.1038/s43018-019-0004-z).
Design target-focused in vitro antibody discovery strategies and
carry out discovery campaigns using synthetic, nave and immunized
Apply in vitro display, molecular biology, high throughput
screening, kinetic profiling and rational antibody engineering
techniques to generate novel biotherapeutics to target the immune
Develop and implement HT biochemical assays (ELISA, flow
cytometry, SPR, etc.) in support of hit identification.
Deep mine NGS data sets from in vitro discovery campaigns.
Bring new ideas for scientific innovation / technology
development and champion them to proof-of-concept studies.
Carry out lead optimization campaigns such as affinity
maturation, pH-dependent binding, etc.
Act as a biologics core project team member to provide technical
guidance and leadership to pre-clinical project teams.
Manage several projects simultaneously and act as point of
accountability for in vitro display efforts on projects.
Work collaboratively with other antibody discovery teams,
locally and globally.
Participate in scientific due diligences of external platform
and asset in-licensing opportunities.
Analyze and present data, both in written reports and oral
- Effectively manage projects and resources to maximize
PhD in Biochemistry, Molecular or Structural Biology or a
closely related field + 3 years of relevant experience in academic
or biopharmaceutic setting or MS + 5 years of relevant experience
or BS +8 years of relevant experience.
Sound understanding and record of accomplishment in antibody
Hands-on experience with antibody phage/yeast display, HT
screening, flow cytometry and kinetic analysis is required.
Experience with library construction, NGS/deep mining,
multi-specific modalities, alternative antibody scaffolds,
interleukin biology and engineering is highly preferred.
Highly analytical mind, attention to detail, and organizational
skills are critical.
Self-starter with a strong sense of responsibility, integrity,
and a collaborative spirit.
- Ability to work independently to design and trouble-shoot
Important note: Large Molecule Research laboratory will relocate
to Cambridge, MA in Q2 2022. The geographic location of this
position in Framingham is therefore only temporary (through Q2
Sanofi Inc. and its U.S. affiliates are Equal Opportunity and
Affirmative Action employers committed to a culturally diverse
workforce. All qualified applicants will receive consideration for
employment without regard to race; color; creed; religion; national
origin; age; ancestry; nationality; marital, domestic partnership
or civil union status; sex, gender, gender identity or expression;
affectional or sexual orientation; disability; veteran or military
status or liability for military status; domestic violence victim
status; atypical cellular or blood trait; genetic information
(including the refusal to submit to genetic testing) or any other
characteristic protected by law.
At Sanofi diversity and inclusion is foundational to how we
operate and embedded in our Core Values. We recognize to truly tap
into the richness diversity brings we must lead with inclusion and
have a workplace where those differences can thrive and be
leveraged to empower the lives of our colleagues, patients and
customers. We respect and celebrate the diversity of our people,
their backgrounds and experiences and provide equal opportunity for
Keywords: Principia Biopharma Inc., Framingham , Senior Scientist, Other , Framingham, Massachusetts
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