Senior Scientist, Genomic Medicine Bioanalytics
Company: Sanofi
Location: Framingham
Posted on: February 22, 2021
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Job Description:
Senior Scientist, Genomic Medicine Bioanalytics From Research
and Development to Sales and Marketing, Sanofi offers a wide range
of possibilities. Discover our open positions and become a health
journey partner. Do you have what it takes for a successful career
with Sanofi? The Genomic Medicine Unit (GMU) CMC group at Sanofi is
dedicated to the establishment of best in class manufacturing
platforms to support development of life-changing advanced cell and
gene therapy products, including recombinant AAV vectors,
lentiviral vectors and cell therapy products.--We are seeking a
motivated PhD level scientist to join our Bioanalytics
Characterization group in Genomic Medicine unit. The Bioanalytics
Characterization group utilizes advanced analytical techniques for
in-depth structural and functional characterization of gene
therapy/cell therapy in support of drug development, from
pre-candidate selection through commercialization. Key
Responsibilities: Develop strategies and technologies to
characterize various biopharmaceutical candidates of viral vectors
for gene therapy and cell therapy. Perform proteomics, genomic,
biochemical and biophysical characterization techniques, such as
PCR (qPCR/ddPCR), southern blotting, MS, CE, AUC, viral protein
profiling and peptide mapping to support batch characterization,
IND enabling studies, forced degradation and comparability studies.
Design and perform structure -function studies in collaboration
with analytical development, process development and research.
Perform and/or coordinate protein engineering studies such as site
direct mutagenesis of viral proteins to allow structure function
analysis. Support cell line clone selection, process development
and formulation. Author technical reports, study protocols and
articles for publication; contribute to scientific literature and
conferences. Write analytical sections of IND/IMPD filings. Mentor
and provide technical oversight for junior team members Basic
Qualifications: A Ph.D. degree in a Biochemistry, Biophysics, or
Chemistry-related field with a minimum of 4 years of relevant
industry experience or a Masters degree with a minimum of 8 years
of relevant industry experience or a Bachelors degree with a
minimum of 10 years of relevant industry experience In depth
knowledge and hands-on experience in molecular techniques, and
separation sciences (e.g. LC-MS, HPLC) or biophysical analysis.
Experience leading the implementation new technologies for the
analysis of gene therapy and cell therapy. Experience
characterizing proteins, viral vectors or cell therapies using
multiple tools and orthogonal data to build and study protein and
viral degradation and behavior. Excellent organizational,
interpersonal, communication and problem-solving skills Preferred
Qualifications: Experience with other chromatographic techniques
such as CE, SEC or IEX. Experience in the characterization of gene
therapy (AAV & lentivirus)/cell therapy products and deep
understanding of these products. Experience perform site
mutagenesis and other protein engineering techniques. Hands-on
experience with particle analysis and thermal stability (DLS &
DSF). Sanofi Inc. and its U.S. affiliates are Equal Opportunity and
Affirmative Action employers committed to a culturally diverse
workforce. All qualified applicants will receive consideration for
employment without regard to race; color; creed; religion; national
origin; age; ancestry; nationality; marital, domestic partnership
or civil union status; sex, gender, gender identity or expression;
affectional or sexual orientation; disability; veteran or military
status or liability for military status; domestic violence victim
status; atypical cellular or blood trait; genetic information
(including the refusal to submit to genetic testing) or any other
characteristic protected by law. #GD-SA #LI-SA At Sanofi diversity
and inclusion is foundational to how we operate and embedded in our
Core Values. We recognize to truly tap into the richness diversity
brings we must lead with inclusion and have a workplace where those
differences can thrive and be leveraged to empower the lives of our
colleagues, patients and customers. We respect and celebrate the
diversity of our people, their backgrounds and experiences and
provide equal opportunity for all. Join our Talent Network and get
Sanofi communications delivered to your inbox. By submitting your
information, you acknowledge that you have read our privacy policy
and consent to receive email communication from Sanofi.
Keywords: Sanofi, Framingham , Senior Scientist, Genomic Medicine Bioanalytics, Healthcare , Framingham, Massachusetts
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