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Senior Scientist, Genomic Medicine Bioanalytics

Company: Sanofi
Location: Framingham
Posted on: February 22, 2021

Job Description:

Senior Scientist, Genomic Medicine Bioanalytics From Research and Development to Sales and Marketing, Sanofi offers a wide range of possibilities. Discover our open positions and become a health journey partner. Do you have what it takes for a successful career with Sanofi? The Genomic Medicine Unit (GMU) CMC group at Sanofi is dedicated to the establishment of best in class manufacturing platforms to support development of life-changing advanced cell and gene therapy products, including recombinant AAV vectors, lentiviral vectors and cell therapy products.--We are seeking a motivated PhD level scientist to join our Bioanalytics Characterization group in Genomic Medicine unit. The Bioanalytics Characterization group utilizes advanced analytical techniques for in-depth structural and functional characterization of gene therapy/cell therapy in support of drug development, from pre-candidate selection through commercialization. Key Responsibilities: Develop strategies and technologies to characterize various biopharmaceutical candidates of viral vectors for gene therapy and cell therapy. Perform proteomics, genomic, biochemical and biophysical characterization techniques, such as PCR (qPCR/ddPCR), southern blotting, MS, CE, AUC, viral protein profiling and peptide mapping to support batch characterization, IND enabling studies, forced degradation and comparability studies. Design and perform structure -function studies in collaboration with analytical development, process development and research. Perform and/or coordinate protein engineering studies such as site direct mutagenesis of viral proteins to allow structure function analysis. Support cell line clone selection, process development and formulation. Author technical reports, study protocols and articles for publication; contribute to scientific literature and conferences. Write analytical sections of IND/IMPD filings. Mentor and provide technical oversight for junior team members Basic Qualifications: A Ph.D. degree in a Biochemistry, Biophysics, or Chemistry-related field with a minimum of 4 years of relevant industry experience or a Masters degree with a minimum of 8 years of relevant industry experience or a Bachelors degree with a minimum of 10 years of relevant industry experience In depth knowledge and hands-on experience in molecular techniques, and separation sciences (e.g. LC-MS, HPLC) or biophysical analysis. Experience leading the implementation new technologies for the analysis of gene therapy and cell therapy. Experience characterizing proteins, viral vectors or cell therapies using multiple tools and orthogonal data to build and study protein and viral degradation and behavior. Excellent organizational, interpersonal, communication and problem-solving skills Preferred Qualifications: Experience with other chromatographic techniques such as CE, SEC or IEX. Experience in the characterization of gene therapy (AAV & lentivirus)/cell therapy products and deep understanding of these products. Experience perform site mutagenesis and other protein engineering techniques. Hands-on experience with particle analysis and thermal stability (DLS & DSF). Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law. #GD-SA #LI-SA At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all. Join our Talent Network and get Sanofi communications delivered to your inbox. By submitting your information, you acknowledge that you have read our privacy policy and consent to receive email communication from Sanofi.

Keywords: Sanofi, Framingham , Senior Scientist, Genomic Medicine Bioanalytics, Healthcare , Framingham, Massachusetts

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