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Senior Principal Scientist, Protein Engineering, Lab Head

Company: Sanofi
Location: Framingham
Posted on: May 12, 2022

Job Description:

We are seeking a passionate and highly experienced Protein Designer to join our Protein Engineering group within Sanofi US Large Molecule Research (LMR) Department. Protein Engineering group has a great track record of patent and publication in the areas of Fc engineering and multispecific antibodies. We have a state-of-art structure biology capability within the group, offering a unique opportunity to collaborate closely on Protein Engineering projects. This Lab Head (Senior Principal Scientist) position will lead a small team of scientists to work closely within a dynamic, fast-paced and highly collaborative environment of Protein Engineering group. The successful candidate should be an expert in creatively applying structure-guided design principles to diverse therapeutic biologics modalities to engineer molecular formats or attributes, such as affinity, activity or developability. Previous experience in designing multispecific/multivalent antibody formats and Fc-engineered fusion molecules in the Oncology, Immuno-Oncology or Immunology & Inflammation therapeutic area is required. S/he must have deep understanding of protein science to provide technical insights and strategies to characterize and interpret biochemical, biophysical and functional attributes of engineered biologics. In addition, s/he will represent LMR Department in cross-functional project teams to identify opportunities in discovery biology enabled by protein engineering and provide the strategy. Previous experience in project and people management is required. Previous experience in Genedata Biologics strongly preferred. Strong interest or experience in other areas of protein engineering, such as glycoengineering and chemical conjugation, or in the area of computational biology , such as in silico structure modeling and analysis, machine learning and de novo design, will be preferred.RESPONSIBILITIES:Develop and engineer bi-specific and multi-specific antibody-based therapeutics and fusion proteins through structure-based design, with the focus on Oncology, Immuno-oncology and Immunology & InflammationProvide technical strategy and insights to screen and analyze the engineered biotherapeutics for improved biological properties, biochemical and biophysical characteristicsActively interact with Therapeutic Area project teams to identify and provide a protein engineering strategy and lead the effortRepresent Large Molecule Research (LMR) Department in cross-functional project teams, coordinate/lead the LMR activities, and work closely together with the Therapeutic Area Project Lead for milestone transitionsManage and develop a team of 3 PhD scientists and 3 junior scientists, and supervise their projectsDocument and present experimental results, conclusions and interpretations at departmental and cross-functional project team meetingsWrite scientific publications and present at conferences. Contribute to patent applications.QUALIFICATIONS:Ph.D degree in Biochemistry/ Molecular Biology/ Structural Biology or a related discipline, with 10 years of industry experience in Biotech/Pharmaceutical environmentSelf-motivated and highly collaborative to work in a cross-cultural, multidisciplinary, team-oriented environment with excellent oral and written communication skills and organization skillsStrong desire to identify and drive technical innovation in protein engineeringProven expertise in antibody/protein design projects in the area of Immuno-Oncology or Immunology & Inflammation, especially multispecific or multivatlent antibody format engineering, Fc-fusions and Fc engineeringWell-versed in structure biology, protein production, protein engineering technologies and principles, including molecular biology, mutagenesis methods, antibody/protein structure-function relationships, biophysical/biochemical analysisExperienced in a wide range of screening assays and (high-throughput) analytical and biophysical methods, such as ELISA, ALPHAScreen, Octet, Biacore, MSD, Carterra, iQue Screener, HPLC/UPLC, DSC/DSF, MALS ; Experience with mass spectrometry a plusExperienced in protein expression in mammalian and bacterial expression system, yeast/phage display library, protein purification, flow cytometry and cell-based and/or immune assaysTrack record of scientific accomplishments as evidenced by a strong publication recordPrior experience in project and people management requiredPrior experience in Genedata Biologics strongly preferredStrong interest or experience in other areas of protein engineering, such as glycoengineering and chemical conjugation, or in the area of computational biology , such as in silico structure modeling and analysis, machine learning and de novo design, will be preferredProtein modeling and in silico analysis using PyMOL, Rosetta, MOE, Discovery Studio or a similar tool a plusFamiliarity with antibody discovery techniques and workflow preferredAt Sanofi R&D North America, we deliver meaningful solutions for patients. We transform science into breakthrough, best-in-class and first-in-class medicines and vaccines. We believe in creating a diverse and inclusive workforce - and workplace - which brings together the collective brainpower of over 2,000 colleagues and provides you with an exciting place to grow and develop. We set the bar high, and we deliver. Join us and together we will build on our trusted legacy of breakthroughs for society.As a healthcare company and a vaccine manufacturer, Sanofi has an important responsibility to protect individual and public health.This position will require individuals to be fully vaccinated against COVID-19 as part of your job responsibilities.Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.GD-SALI-SAPDNAt Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.PDN-957dc4aa-74c2-451a-b307-c6d0dae89725

Keywords: Sanofi, Framingham , Senior Principal Scientist, Protein Engineering, Lab Head, Engineering , Framingham, Massachusetts

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